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  • 标题:Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men
  • 本地全文:下载
  • 作者:Graham C. Burdge ; Berit Lupoli ; Jennifer J. Russell
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2004
  • 卷号:45
  • 期号:4
  • 页码:736-741
  • DOI:10.1194/jlr.M300447-JLR200
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:This study investigated the incorporation of cis -9, trans -11 conjugated linoleic acid (c9,t11 CLA) and trans -10, cis -12-CLA (t10,c12 CLA) into plasma and peripheral blood mononuclear cell (PBMC) lipids when consumed as supplements highly enriched in these isomers. Healthy men (n = 49, age 31 ± 8 years) consumed one, two, and four capsules containing ∼600 mg of either c9,t11 CLA or t10,c12 CLA per capsule for sequential 8 week periods followed by a 6 week washout before consuming the alternative isomer. Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P r = 0.706, t10,c12 CLA r = 0.788; P r = 0.285 and r = 0.273, respectively; P These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily.
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