出版社：American Society for Biochemistry and Molecular Biology
摘要：This study investigated the incorporation of cis -9, trans -11 conjugated linoleic acid (c9,t11 CLA) and trans -10, cis -12-CLA (t10,c12 CLA) into plasma and peripheral blood mononuclear cell (PBMC) lipids when consumed as supplements highly enriched in these isomers. Healthy men (n = 49, age 31 ± 8 years) consumed one, two, and four capsules containing ∼600 mg of either c9,t11 CLA or t10,c12 CLA per capsule for sequential 8 week periods followed by a 6 week washout before consuming the alternative isomer. Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P r = 0.706, t10,c12 CLA r = 0.788; P r = 0.285 and r = 0.273, respectively; P These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily.
