出版社：American Society for Biochemistry and Molecular Biology
摘要：The VLDL receptor (VLDLr) is involved in tissue delivery of VLDL-triglyceride (TG)-derived FFA by facilitating the expression of lipoprotein lipase (LPL). However, vldlr −/ − mice do not show altered plasma lipoprotein levels, despite reduced LPL expression. Because LPL activity is crucial in postprandial lipid metabolism, we investigated whether the VLDLr plays a role in chylomicron clearance. Fed plasma TG levels of vldlr −/ − mice were 2.5-fold increased compared with those of vldlr +/ + littermates (1.20 ± 0.37 mM vs. 0.47 ± 0.18 mM; P vldlr −/ − compared with vldlr +/ + mice (226 ± 188 mM/h vs. 25 ± 11 mM/h; P 3H]TG-labeled protein-free chylomicron-mimicking emulsion particles was delayed in vldlr −/ − compared with vldlr +/ + mice (half-life of 12.0 ± 2.6 min vs. 5.5 ± 0.9 min; P P 14C]FFA, indicating that the VLDLr facilitates postprandial LPL-mediated TG hydrolysis rather than mediating FFA uptake. We conclude that the VLDLr plays a major role in the metabolism of postprandial lipoproteins by enhancing LPL-mediated TG hydrolysis.
