出版社：American Society for Biochemistry and Molecular Biology
摘要：Hypertriglyceridemia is considered a cardiovascular risk factor in diabetic and nondiabetic subjects. In this study, we aimed to determine potential regulators of very low density lipoprotein-triglyceride (TG) production. VLDL-TG kinetics were measured in 13 men and 12 women {body mass index [mean (range)]: 24.8 (20.2–35.6) kg/m2}. VLDL-TG production was assessed from the plasma decay of a bolus injection of ex vivo labeled VLDL particles ([1-14C]triolein-VLDL-TG). Similar VLDL-TG production (μmol/min) was found in men and women. VLDL-TG production was not significantly correlated with palmitate flux ([9,10-3H]palmitate) ( r = 0.09, P = 0.67) or palmitate concentration ( r = −0.29, P = 0.2) but was correlated significantly with fasting insulin concentration ( r = 0.46, P r = 0.45, P P = 0.02) and REE ( P = 0.02) ( r 2 = 0.32, P
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