出版社：American Society for Biochemistry and Molecular Biology
摘要：Phosphatidylcholine transfer protein (PC-TP) is a cytosolic phospholipid binding protein and a member of the steroidogenic acute regulatory-related transfer domain superfamily. Its tissue distribution includes liver and macrophages. PC-TP regulates hepatic lipid metabolism, and its absence in cholesterol-loaded macrophages is associated with reduced ATP binding cassette transporter A1-mediated lipid efflux and increased susceptibility to apoptosis induced by unesterified cholesterol. To explore a role for PC-TP in atherosclerosis, we prepared PC-TP-deficient/apolipoprotein E-deficient ( Pctp −/−/ Apoe −/−) mice and littermate Apoe −/− controls. At 16 weeks, atherosclerosis was increased in chow-fed male, but not female, Pctp −/−/ Apoe −/− mice. This effect was associated with increases in plasma lipid concentrations. By contrast, no differences in atherosclerosis were observed between male or female Pctp −/−/ Apoe −/− mice and Apoe −/− controls fed a Western-type diet for 16 weeks. At 24 weeks, atherosclerosis in chow-fed male Pctp −/−/ Apoe −/− mice tended to be reduced in proportion to plasma cholesterol. The attenuation of atherosclerosis in female Pctp −/−/ Apoe −/− mice fed chow or the Western-type diet for 24 weeks was not attributable to changes in plasma cholesterol or triglyceride concentrations. These findings suggest that PC-TP modulates the development of atherosclerosis, in part by regulating plasma lipid concentrations.
Loading...
