文章基本信息

标题：Vitamin A combined with retinoic acid increases retinol uptake and lung retinyl ester formation in a synergistic manner in neonatal rats
作者：A. Catharine Ross ; Namasivayam Ambalavanan ; Reza Zolfaghari 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2006
卷号：47
期号：8
页码：1844-1851
DOI：10.1194/jlr.M600061-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Vitamin A (VA) is stored in tissues predominantly as retinyl esters (REs), which provide substrate for the production of bioactive retinoids. Retinoic acid (RA), a principal metabolite, has been shown to induce postnatal lung development. To better understand lung RE storage, we compared VA (given as retinyl palmitate), RA, and a nutrient-metabolite combination, VARA, given orally on postnatal days 5–7, for their ability to increase lung RE in neonatal rats. VARA increased lung RE significantly [∼14, 2.4, 2.1, and P 3H]retinol with VARA, compared with VA or C, increased the uptake of newly absorbed ³H by 3-fold, indicating that VARA stimulated the uptake of [³H]retinol and its retention as [³H]RE in neonatal lungs. After cessation of VARA, lung RE remained increased for 9 d afterward, through the period of alveolar development. In conclusion, VARA, a 10:1 nutrient-metabolite combination, increased lung RE significantly compared with VA alone and could be a promising therapeutic option for enhancing the delivery of VA to the lungs.