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  • 标题:Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects
  • 本地全文:下载
  • 作者:Giovanna Catalano ; Emilie Duchene ; Zélie Julia
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2008
  • 卷号:49
  • 期号:3
  • 页码:635-643
  • DOI:10.1194/jlr.M700510-JLR200
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:We evaluated the impact of gender differences in both the quantitative and qualitative features of HDL subspecies on cellular free cholesterol efflux through the scavenger receptor class B type I (SR-BI), ABCA1, and ABCG1 pathways. For that purpose, healthy subjects (30 men and 26 women) matched for age, body mass index, triglyceride, apolipoprotein A-I, and high density lipoprotein-cholesterol (HDL-C) levels were recruited. We observed a significant increase (+14%; P 2 particles (+20%; P P P P r = 0.72, P
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