出版社：American Society for Biochemistry and Molecular Biology
摘要：The HDL and LDL subclass profile is an emerging cardiovascular risk factor. Yet, the biological and genetic mechanisms controlling the lipoprotein subclass distribution are unclear. Therefore, we aimed 1 ) to determine the heritability of the entire spectrum of LDL and HDL subclass features and 2 ) to identify gene loci influencing the lipoprotein subfraction pattern. Using NMR spectroscopy, we analyzed the lipoprotein subclass distribution in 1,275 coronary artery disease patients derived from the Regensburg Myocardial Infarction Family Study. We calculated heritabilities, performed a microsatellite genome scan, and calculated linkage. HDL and LDL subclass profiles showed heritabilities ranging from 23% to 67% (all P −3) of traits using univariate calculation. After multivariate adjustment, we found heritabilities of 27–48% (all P
