出版社：American Society for Biochemistry and Molecular Biology
摘要：Administered subcutaneously, D-4F or L-4F are equally efficacious, but only D-4F is orally efficacious because of digestion of L-4F by gut proteases. Orally administering niclosamide (a chlorinated salicylanilide used as a molluscicide, antihelminthic, and lampricide) in temporal proximity to oral L-4F (but not niclosamide alone) in apoE null mice resulted in significant improvement ( P P P = 0.02), en face lesion area ( P = 0.033), and macrophage lesion area ( P = 0.02) compared with pretreatment, indicating lesion regression. In contrast, lesions were significantly larger in mice receiving only niclosamide and pravastatin or L-4F and pravastatin ( P J. Lipid Res. 2009. 50: 1538–1547.
