出版社：American Society for Biochemistry and Molecular Biology
摘要：Scavenger receptor BI (SR-BI) is a selective uptake receptor for HDL cholesterol but is also involved in the catabolism of apolipoprotein (apo)B-containing lipoproteins. However, plasma levels of apoB-containing lipoproteins increase following hepatic SR-BI overexpression, suggesting that SR-BI not solely mediates their catabolism. We therefore tested the hypothesis that hepatic SR-BI impacts on VLDL production. On day 7 following adenovirus (Ad)-mediated overexpression of SR-BI, VLDL-triglyceride and VLDL-apoB production rates were significantly increased ( P P P P P P
关键词：triglycerides ; cholesterol ; liver ; hepatocytes ; labeling ; high density lipoproteins ; microsomal triglyceride transfer protein ; apolipoprotein B
