标题：APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians
出版社：American Society for Biochemistry and Molecular Biology
摘要：Apolipoprotein (apo) C-I is a constituent of chylomicrons, very low density lipoprotein, and high density lipoprotein. The role of apo C-I in human metabolism is incompletely defined. We took advantage of a naturally occurring amino acid polymorphism that is present in aboriginal North Americans, namely apo C-I T45S. We assessed the hypothesis that metabolic traits, including obesity-related and lipoprotein-related traits, would differ between carriers and noncarriers of apo C-I T45S. A genotyping assay was developed for APOC1 T45S and genotypes were determined in a sample of 410 Canadian Oji-Cree subjects. The allele frequency of the apo C-I S45 allele was ∼8% in this sample. We observed the apo C-I S45 allele was significantly associated with 1 ) lower percent body fat ( P 2 ) lower waist circumference ( P = 0.058), 3 ) lower serum leptin levels ( P 4 ) lower plasma apo C-I levels ( P
关键词：nonsynonymous variant ; leptin ; Canadian First Nation population ; genetics ; serum levels ; hypertriglyceridemic waist
