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  • 标题:Genetic determinants of hepatic steatosis in man
  • 本地全文:下载
  • 作者:Amanda J. Hooper ; Leon A. Adams ; John R. Burnett
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2011
  • 卷号:52
  • 期号:4
  • 页码:593-617
  • DOI:10.1194/jlr.R008896
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:Hepatic steatosis is one of the most common liver disorders in the general population. The main cause of hepatic steatosis is nonalcoholic fatty liver disease (NAFLD), representing the hepatic component of the metabolic syndrome, which is characterized by type 2 diabetes, obesity, and dyslipidemia. Insulin resistance and excess adiposity are considered to play key roles in the pathogenesis of NAFLD. Although the risk factors for NAFLD are well established, the genetic basis of hepatic steatosis is largely unknown. Here we review recent progress on genomic variants and their association with hepatic steatosis and discuss the potential impact of these genetic studies on clinical practice. Identifying the genetic determinants of hepatic steatosis will lead to a better understanding of the pathogenesis and progression of NAFLD.
  • 关键词:alcoholic fatty liver disease ; cirrhosis ; fibrosis ; genetic factors ; gene variants ; nonalcoholic fatty liver disease ; nonalcoholic steatohepatitis ; single nucleotide polymorphisms ; susceptibility
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