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  • 标题:Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice
  • 本地全文:下载
  • 作者:Clémentine Thabuis ; Frédéric Destaillats ; Didier M. Lambert
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2011
  • 卷号:52
  • 期号:7
  • 页码:1373-1382
  • DOI:10.1194/jlr.M013391
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:We evaluated the biological basis of reduced fat gain by oleoylethanolamide (OEA) in high-fat-fed mice and sought to determine how degradation of OEA affected its efficiency by comparing its effects to those of KDS-5104, a nonhydrolyzable lipid OEA analog. Mice were given OEA or KDS-5104 by the oral route (100 mg/kg body weight). Sixty-eight variables per mouse, describing six biological processes (lipid transport, lipogenesis, energy intake, energy expenditure, endocannabinoid signaling, and glucose metabolism), spanning gene expression of biochemical and physiological parameters were examined to determine the primary target whereby OEA reduces fat gain. Although KDS-5104 but not OEA was resistant to fatty acid amide hydrolase hydrolysis, OEA was degraded by an unidentified hydrolysis system in the liver. Nevertheless, both compounds equally decreased body fat pads after 5 weeks (20%; P P
  • 关键词:endocannabinoid ; indirect calorimetry ; nutrigenomics ; PLS
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