出版社:American Society for Biochemistry and Molecular Biology
摘要:Type I diabetes mellitus (T1DM) increases atherosclerotic cardiovascular disease; however, the underlying pathophysiology is still incompletely understood. We investigated whether experimental T1DM impacts HDL-mediated reverse cholesterol transport (RCT). C57BL/6J mice with alloxan-induced T1DM had higher plasma cholesterol levels ( P P P P P P P P P 3H]cholesterol-loaded primary mouse macrophage foam cells, was 20% lower in T1DM ( P P P P
关键词:high density lipoproteins ; bile acids ; cardiovascular disease ; atherosclerosis ; neutral sterols ; glucose ; efflux ; selective uptake ; liver ; bile