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  • 标题:Type I diabetes mellitus decreases in vivo macrophage-to-feces reverse cholesterol transport despite increased biliary sterol secretion in mice
  • 本地全文:下载
  • 作者:Jan Freark de Boer ; Wijtske Annema ; Marijke Schreurs
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2012
  • 卷号:53
  • 期号:3
  • 页码:348-357
  • DOI:10.1194/jlr.M018671
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:Type I diabetes mellitus (T1DM) increases atherosclerotic cardiovascular disease; however, the underlying pathophysiology is still incompletely understood. We investigated whether experimental T1DM impacts HDL-mediated reverse cholesterol transport (RCT). C57BL/6J mice with alloxan-induced T1DM had higher plasma cholesterol levels ( P P P P P P P P P 3H]cholesterol-loaded primary mouse macrophage foam cells, was 20% lower in T1DM ( P P P P
  • 关键词:high density lipoproteins ; bile acids ; cardiovascular disease ; atherosclerosis ; neutral sterols ; glucose ; efflux ; selective uptake ; liver ; bile
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