出版社：American Society for Biochemistry and Molecular Biology
摘要：In familial hypercholesterolemia (FH), low HDL cholesterol (HDL-C) levels are associated with functional alterations of HDL particles that reduce their capacity to mediate the reverse cholesterol transport (RCT) pathway. The objective of this study was to evaluate the consequences of LDL apheresis on the efficacy of the RCT pathway in FH patients. LDL apheresis markedly reduced abnormal accelerated cholesteryl ester transfer protein (CETP)-mediated cholesteryl ester (CE) transfer from HDL to LDL, thus reducing their CE content. Equally, we observed a major decrease (−53%; P P P P P
关键词：cholesteryl ester transfer protein ; low density lipoprotein ; high density lipoprotein ; cellular cholesterol efflux ; high density lipoprotein cholesteryl ester uptake
