出版社：American Society for Biochemistry and Molecular Biology
摘要：Cholesteryl ester transfer protein (CETP) facilitates the transfer of HDL cholesteryl ester to triglyceride-rich lipoproteins (TRL). This study aimed to determine the effects of CETP inhibition with torcetrapib on TRL composition and apoB-48 metabolism. Study subjects with low HDL cholesterol ( 2H3]L-leucine, while in the constantly fed state, to determine the kinetics of TRL apoB-48 and TRL composition. Relative to placebo, torcetrapib markedly reduced TRL CE levels in all groups (≥−69%; P P = 0.007; PR: −49%, P = 0.005) and twice daily (PS: −30%, P = 0.01; PR: −27%, P = 0.13) cohorts. In the atorvastatin cohort, apoB-48 PS and PR, which were already lowered by atorvastatin, did not change with torcetrapib. Our findings indicate that CETP inhibition reduced plasma apoB-48 concentrations by reducing apoB-48 production but did not have this effect in subjects already treated with atorvastatin.
关键词：cholesteryl ester transfer protein ; apolipoprotein ; lipoprotein kinetics ; postprandial metabolism ; torcetrapib
