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  • 标题:Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice
  • 本地全文:下载
  • 作者:Abdel K. Salous ; Manikandan Panchatcharam ; Manjula Sunkara
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2013
  • 卷号:54
  • 期号:10
  • 页码:2775-2784
  • DOI:10.1194/jlr.M039685
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:Lysophosphatidic acid (LPA) is a bioactive lipid mediator. Concentrations of the major LPA species in mouse plasma decreased uniformly following administration of a potent selective inhibitor of the LPA-generating lysophospholipase D autotaxin, identifying an active mechanism for removal of LPA from the circulation. LPA, akylglycerol phosphate (AGP), sphingosine 1-phosphate (S1P), and a variety of structural mimetics of these lipids, including phosphatase-resistant phosphonate analogs of LPA, were rapidly eliminated (t1/2
  • 关键词:autotaxin ; lipid phosphate phosphatase ; transcellular uptake ; mass spectrometry
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