出版社：American Society for Biochemistry and Molecular Biology
摘要：Human obesity is associated with decreased triglyceride turnover and impaired lipolysis in adipocytes. We determined whether such defects also occur in subjects with only moderate increase in fat mass. Human abdominal subcutaneous adipose tissue was investigated in healthy, nonobese subjects [body mass index (BMI) > 17 kg/m2 and BMI 2]. Triglyceride age, reflecting lipid turnover, was examined in 41 subjects by assessing the incorporation of atmospheric 14C into adipose lipids. Adipocyte lipolysis was examined as the ability of lipolytic agents to stimulate glycerol release in 333 subjects. Adipocyte triglyceride age was markedly increased in overweight (BMI ≥ 25 kg/m2) compared with lean subjects ( P = 0.017) with triglyceride T1/2 of 14 and 9 months, respectively ( P = 0.04). Triglyceride age correlated positively with BMI ( P = 0.002) but not with adipocyte volume ( P = 0.2). Noradrenaline-, isoprenaline- or dibutyryl cyclic AMP-induced lipolysis was inversely correlated with triglyceride age ( P P
关键词：body mass index ; glycerol ; subcutaneous adipose tissue
