出版社：American Society for Biochemistry and Molecular Biology
摘要：Placental inflammation is associated with several pregnancy disorders. Inflammation is limited by anti-inflammatory and proresolving mechanisms, the latter partly mediated by resolvins and protectins derived from omega-3 polyunsaturated fatty acids (n-3PUFA). We examined effects of dietary n-3PUFAs on levels of resolvins, protectins, and lipoxygenase (ALOX) enzymes in the rat placenta. Rats consumed standard (Std) or high n-3PUFA (Hn3) diets from day 1 of pregnancy; tissues were collected on day 17 or 22 (term = day 23). Maternal Hn3 diet increased resolvin and protectin precursors, 18R/S-HEPE ( P P P Alox15b and Alox5 mRNA expression, while RvD2 increased at both days ( P P Alox15 mRNA expression ( P P Il1β , and Il6 mRNA expression increased marginally with Hn3 at day 22 ( P Ptgs1 ( Cox1 ) expression increased both days ( P
