出版社：American Society for Biochemistry and Molecular Biology
摘要：Recent genome-wide association studies have identified multiple loci robustly associated with plasma lipids, which also contribute to extreme lipid phenotypes. However, these common genetic variants explain PInteraction = 2.87 × 10−4) and HDLc ( PInteraction = 1.05 × 10−3). These interactions were largely driven by SNPs tagging APOA5 , glucokinase receptor ( GCKR ), and LPL for TG, and cholesteryl ester transfer protein ( CETP ), GalNAc-transferase ( GALNT2 ), endothelial lipase ( LIPG ), and phospholipid transfer protein ( PLTP ) for HDLc. In contrast, the GRSLDL cholesterol × adiposity interaction was not significant. Sexual dimorphism was evident for the GRSHDL on HDLc in obese ( PInteraction = 0.016) but not lean subjects. SNP by BMI interactions may provide biological insight into specific genetic associations and missing heritability.
