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  • 标题:Biomedical applications of glycosylphosphatidylinositol-anchored proteins
  • 本地全文:下载
  • 作者:Susanne Heider ; John A. Dangerfield ; Christoph Metzner
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2016
  • 卷号:57
  • 期号:10
  • 页码:1778-1788
  • DOI:10.1194/jlr.R070201
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) use a unique posttranslational modification to link proteins to lipid bilayer membranes. The anchoring structure consists of both a lipid and carbohydrate portion and is highly conserved in eukaryotic organisms regarding its basic characteristics, yet highly variable in its molecular details. The strong membrane targeting property has made the anchors an interesting tool for biotechnological modification of lipid membrane-covered entities from cells through extracellular vesicles to enveloped virus particles. In this review, we will take a closer look at the mechanisms and fields of application for GPI-APs in lipid bilayer membrane engineering and discuss their advantages and disadvantages for biomedicine.
  • 关键词:cancer ; human immunodeficiency virus ; immunology ; lipid rafts ; membranes ; gene therapy ; molecular painting ; tumor therapy ; viral envelope
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