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  • 标题:Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD
  • 本地全文:下载
  • 作者:Arnab Chattopadhyay ; Mohamad Navab ; Greg Hough
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2016
  • 卷号:57
  • 期号:5
  • 页码:832-847
  • DOI:10.1194/jlr.M064352
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn -1 and a hydroxyl group at sn -2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone. Western diet (WD) contained dramatically less phosphatidylcholine 18:1 or LysoPC 18:1 compared with chow, but feeding WD increased LysoPC 18:1 in the jejunum by 7.5 ± 1.4-fold compared with chow. Feeding LysoPC 18:1 or feeding WD increased oxidized phospholipids in the jejunum by 5.2 ± 3.0-fold or 8.6 ± 2.2-fold, respectively, in LDLR-null mice ( P P P P
  • 关键词:lysophosphatidic acid ; lysophosphatidylcholine ; apolipoprotein A-I mimetic peptides ; atherosclerosis ; E06 antibody ; Western diet ; transgenic tomatoes expressing the 6F peptide
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