出版社：American Society for Biochemistry and Molecular Biology
摘要：Incubation of human serum solutions low in glyceride content for 16 hr resulted in a net increase of cholesterol esters in all three major human serum lipoprotein classes, namely the very low-density lipoproteins of d When serum was incubated in the presence of high concentrations of VLDL lipoproteins, the increase in cholesterol esters was found only in the VLDL fraction. The VLDL apparently took up newly-formed cholesterol esters produced by serum fatty acid transferase activity, and accepted some cholesterol esters initially bound to the LDL and HDL. When the transferase was inhibited with sodium p -hydroxymercuribenzoate, some of the cholesterol esters initially bound to the LDL and HDL were still transferred to the VLDL. The HDL class was then the principal contributor of the cholesterol esters. These observations indicate that reciprocal transfer of cholesterol esters for glycerides in human serum lipoproteins can occur.
关键词：serum incubation ; lipoproteins ; lipid transfer ; effect of very low-density lipoproteins ; glycerides ; cholesterol esters ; fatty acid transferase ; inhibition ; transesterification ; ultracentrifugal fractions
