出版社：American Society for Biochemistry and Molecular Biology
摘要：Groups of brains from rats of various ages–7 to 275 days–were analyzed for their contents of galactolipids (cerebroside + cerebroside sulfate), cholesterol, and the individual fatty acids of the gangliosides and glycerophosphatides. Ganglioside stearate was found to accumulate at a steady pace during the first 20 days of life, then more slowly for at least 32 days more, then to decrease. Ganglioside arachidate, on the other hand, accumulated steadily throughout the period covered. The glycerophosphatide acids showed several inversions in the ratios between selected pairs of acids, the trend being toward increasing unsaturation and chain length. Higher contents of 22:6 and 20:4 acids than previously reported were found, presumably because of improved methods. The galactolipids and cholesterol were deposited at very similar rates after about 15 days, the molar ratio of the deposits (cholesterol/galactolipids) being about 2.2, the value found for purified myelin.
