出版社：American Society for Biochemistry and Molecular Biology
摘要：Rats with thoracic duct fistulae were fed triolein and triolein containing various amounts of labeled cholesterol. The analysis of the lymph lipids gave the following results. In the fasting state the cholesterol transported via the thoracic duct was 0.87 μmole/hr. Feeding 800 μmoles of triolein gave a maximum rate of transport of cholesterol of 1.65 μmoles/hr. Addition of cholesterol to the triolein further increased the cholesterol transport to a maximal rate of almost 5 μmoles/hr when 50 μmoles of cholesterol were fed per 800 μmoles of triolein. The exogenous fraction of the cholesterol transported increased linearly with increasing cholesterol load, constituting at the highest dose almost 90% of the total cholesterol transported. An almost constant fraction (about 0.4) of the dietary cholesterol was recovered in the thoracic duct lymph in 24 hr irrespective of the dose fed, from a trace up to 100 μmoles in 800 μmoles of triolein. Cholesterol absorption has the characteristics of a passive diffusion process.
