The informationalized knowledge sharing of MOOCs not only promotes the change of teaching concept and the reform of teaching methodology, but also provides a new opportunity for the teaching resource integration and sharing between different universities. The present study has constructed an e-Portfolio-based model for the application and sharing of college English ESP MOOCs. In this model, college English ESP MOOCs developed by different universities have been put into the e-Portfolio-based platform for application and sharing, and those MOOCs will be applied in the specific ESP teaching and learning processes. It is hoped that the application of the model will accelerate the development, application and sharing of teaching resources, and the coordination and innovation of knowledge between universities, and advance the professional interaction and the cultivation of interdisciplinary talents based on formative assessment.