The following research tries to study the Relationship between key factors of academic innovations and faculties’ teaching goals with the mediatory role of their pedagogical, technological and content knowledge. The statistical population in this research included faculty members of Shiraz University. By simple random sampling, 127 faculty members were selected. The research instruments included of Academic Innovation Factors scale, Knowledge scale and Teaching Goals inventory. The data was analyzed, by structural equation model. Results showed Academic innovation key factors are positive predictor of various faculty members’ teaching goals. Academic innovation key factors are positive predictor of faculty members’ knowledge. Academic innovation key factors with the mediatory role of faculty members is positive predictor of faculty members’ teaching goals.