In the literature, there are various studies relating positively the entrepreneurial orientation to business performance. In such studies a great deal of variables have been introduced to measure business performance, among the variables most accepted by researchers and academics are profit and business growth. Therefore, it is possible to consider that entrepreneurial orientation plays an essential role in business growth. For that reason, this paper has the objective to analyse the existing relationship between entrepreneurial orientation and growth, by using a random sample of 318 small and medium-sixed enterprises in México. The results obtained show that proactivity, risk taking and innovativeness along with the competitive aggression and autonomy have significant and positive effects on small and medium-sized enterprises’ growth.