出版社：National Institute of Occupational Safety and Health
摘要：Individual differences in susceptibility to benzene have been observed. Systematic observations, however, using one kind of animal and one method have not been previously reported. Accordingly, the individual differences in susceptibility to benzene from the viewpoint of environment will be analyzed in the present paper. First of all, the effect of ambient temperatures on susceptibility in chronic benzene poisoning was examined. Thirty male seven-week-old Donryu rats weighing 130 g and bred at 21°C were accli-matized to 32 °C, 21°C and 10°C (relative humidity 55 %) for eight days. The rats were then given subcutaneous injections of 1.0 g/kg of benzene or same dose of olive oil for twelve successive days. Every four days blood taken from the tail was examined. The body weight of the benzene injected rats showed a decrease at all temperatures. Significant leucopenia was observed at 32°C and 21°C, while no change of leucocyte count occured at 10°C. From the above results, the rats exposed to a cold temperature were felt to be mini-mally intoxicated by benzene as compared with the rats exposed to the moderate or high temperatures.
