出版社：National Institute of Occupational Safety and Health
摘要：The effect of phenobarbital on the biliary excretion of metals in rats was com-pared among methyl mercury, inorganic mercury and cadmium compounds from which phenobarbital prevented animals. In rats given an i.v. administration of 1mg/kg Cd or Hg, large amounts of cadmium (15.1% of the dose) were found in the bile within 5 hr after the dose, but small amounts of mercury were excreted with bile (1.4 and 3.3% in inorganic mercury and methyl mercury groups, respectively). Phenobarbital significantly increased the biliary excretion of methyl mercury and cadmium (154 and 140% of controls, respectively), but not that of inorganic mercury. Concentrations of methyl mercury in the bile also increased in the treated rats, but those of cadmium did not change when compared with controls. Distribution of those metals in organs was not affected significantly by phenobarbital except for an increase in mercury content in blood obtained from rats given methyl mercury. These different effects of phenobarbital may reflect individual feature of in metabolism of three metals in the liver and those affinity to tissues.
