出版社：National Institute of Occupational Safety and Health
摘要：The change of convulsion threshold in the rat exposed to toluene was studied in an attempt to experimentally confirm the clinical experience that paroxysm-like abnormal EEGs by injection of 50mg Bemegride and the attacks of syncope or con-vulsion occurred in some patients exposed mainly to toluene. Sprague-Dawley strain male rats had been exposed to 2, 000 ppm toluene vapor 8 hr a day for 8 weeks, and convulsion threshold and body weight were observed. he body weight of the exposed group did not increase during the first week of exposure to 2, 000 ppm toluene, but steadily increased afterward. The body weight of the exposed rats was constantly kept a little less than the control during the exposure, with no significant staistical difference. he convulsion threshold was determined by the peritoneal injection of Bemegride. The total sum of Bemegride injected in a rat till the beginning of convulsion was regarded as convulsion threshold. The convulsion threshold of the exposed group steadily became smaller than the control from 1 to 6 weeks after the beginning of exposure and there were significant statistical differences between the two groups, but after 8 weeks the convulsion threshold became larger a little and there was no significant difference. The decrease in the convulsion threshold by Bemegride suggests that some func-tional and/or organic changes should occur in the central nervous system owing to the exposure to toluene vapor.
