摘要：Activity-guided fractionation of an 80% EtOH extract from the aerial parts of Saururus chinensis led to isolation of three anti-proliferative neolignans ( 1 – 3 ) along with four flavonoids ( 4 – 7 ) and four aristolactams ( 8 – 11 ). Their chemical structures were identified by analysis of spectroscopic data. All compounds 1 – 11 were evaluated for their activities against 28 human cancer cell lines using an in vitro cell proliferation assay. Compounds 1 – 3 showed potent anti-proliferative activities against cervical (C33a, IC50=0.01 µ M for 1 ; 0.28 µ M for 2 ; 2.80 µ M for 3 ) and lung (NCI-H460, IC50=0.05 µ M for 1 ; 1.37 µ M for 2 ; 6.46 µ M for 3 ) cancer cells without any remarkable cytotoxic effects on human normal lung cells as a control. Taken together, these data demonstrated the identification of anti-proliferative neolignans which are active components of S. chinensis .
关键词：Saururus chinensis;neolignan;anti-proliferation;anti-cancer;medicinal herb
