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  • 标题:Antifungal Activity of Hinokitiol-Related Compounds on Wood-Rotting Fungi and Their Insecticidal Activities
  • 本地全文:下载
  • 作者:Yoshihiko INAMORI ; Yoshikazu SAKAGAMI ; Yasuhiro MORITA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2000
  • 卷号:23
  • 期号:8
  • 页码:995-997
  • DOI:10.1248/bpb.23.995
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Hinokitiol (β-thujaplicin), β-dolabrin and γ-thujaplicin isolated from Thujopsis dolabrata SIEB, et ZUCC. var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their mininum inhibitory concentration (MIC) values being 0.2 μg/ml. Their antifungal activities on D. dickinsii IFO-4979 were as high as that of amphotericin B used as a positive control. Three compounds had strong insecticidal activities on Tyrophagus putrescentiae [50%-lethal concentration (LC50 : g/m2) 0.25 in hinokitiol, 0.02 in β-dolabrin and γ-thujaplicin]. Their insecticidal activities were higher than that of N, N-diethyl-m-toluamide (DEET, LC50 : 1.46 g/m2) used as a positive control. Three compopunds also showed strong insecticidal activity on Coptotermes formosanus [LC50 (g/m2) 0.07 in hinokitiol, 0.05 in β-dolabrin and γ-thujaplicin], although their insecticidal activities were much lower than that of commerical chloropyrifos (LC50 : 0.00016 g/m2).
  • 关键词:hinokitiol;β-dolabrin;γ-thujaplicin;antifungal activity;wood-rotting fungus;insecticidal activity
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