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  • 标题:Differentiation-Inducing Effect of Magnolialide, a 1β-Hydroxyeudesmanolide Isolated from Cichorium intybus, on Human Leukemia Cells
  • 本地全文:下载
  • 作者:Kyung-Tae LEE ; Joo-Il KIM ; Hee-Juhn PARK
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2000
  • 卷号:23
  • 期号:8
  • 页码:1005-1007
  • DOI:10.1248/bpb.23.1005
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Cichorium intypbus contains two 1β-hydroxyeudesmanolides, magnolialide and artesin, together with several constituents. Magnolialide inhibits the growth of several tumor cell lines and appears to induce differentiation of human leukemia HL-60 and U-937 cells to monocyte/macrophage-like cells. Another 1β-hydroxyeudesmanolide, artesin, and other consitutents were inactive. The content of magnolialide was shown to be highest in the leaves of Inje cultivar among the cultivars investigated in this study.
  • 关键词:Magnolialide;1β-hydroxyeudesmanolide;growth-inhibitory activity;differentiation;leukemia cells;Cichorium intybus
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