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  • 标题:Reaction of Malondialdehyde with Deoxyribonucleosides in the Presence of Acetaldehyde
  • 本地全文:下载
  • 作者:Takeshi OHYA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1994
  • 卷号:17
  • 期号:10
  • 页码:1411-1413
  • DOI:10.1248/bpb.17.1411
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The reactivity of malondialdehyde (MDA) with deoxyribonucleosides in the presence of acetaldehyde (AA) was investigated. Although MDA is known to be reactive towards deoxyguanosine (GdR), deoxyadenosine (AdR) and deoxycytidine (CdR) under acidic conditions, MDA had only slight reactivity towards GdR under physiological pH. However, when AA was present, MDA exhibited much higher reactivity towards GdR, and a reaction with AdR also took place.
  • 关键词:malondialdehyde;nucleoside;acetaldehyde;deoxyguanosine;deoxyadenosine
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