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  • 标题:Utilization of Intravenously Infused Maltooligosaccharides in Rabbits
  • 本地全文:下载
  • 作者:Shuji WATANABE ; Shigeaki MARUO ; Hideya MUKAI
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1993
  • 卷号:16
  • 期号:10
  • 页码:1044-1045
  • DOI:10.1248/bpb.16.1044
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The utilization of intravenously infused maltotriose, maltotetraose and maltopentaose was investigated in rabbits. Rabbits were infused with isotonic solutions of each maltooligosaccharide for 2 h and the utilization was assessed by the 24-h urinary loss of carbohydrates. The utilization of these maltooligosaccharides was good (≥87.5%) at a rate of 1 ml/kg/h (≤250 mg/kg/h) and poor (≤36.2%) at a rate of 5 ml/kg/h (>250 mg/kg/h). Furthermore, these maltooligosaccharides infused as 5% solution showed good utilization (≥86.2%) at a rate of 5 ml/kg/h (250 mg/kg/h). These results suggest the existence of a threshold dose in the utilization of intravenously infused maltooligosaccharides, and this threshold value in rabbits is estimated to be nearly 250 mg/kg/h.
  • 关键词:maltooligosaccharide;utilization;rabbit;intravenous infusion
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