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标题：CARDIAC GLYCOSIDE-INDUCED ELEVATION OF INTRACELLULAR Na+ ION CONCENTRATION IN HUMAN ERYTHROCYTES STUDIED BY 23Na NMR SPECTROSCOPY : RELATIONSHIP BETWEEN INOTROPY SPEED AND ELEVATION RATE OF INTRACELLULAR Na+ ION CONCENTRATION
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作者：Takahiro TANASE ; Nobutoshi MURAKAMI ; Akito NAGATSU 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：4
页码：431-433
DOI：10.1248/bpb.16.431
出版社：The Pharmaceutical Society of Japan
摘要：Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin (1), and its four derivatives (2-5) was measured using ²³Na NMR spectrometry. In this examination, there was a significant correlation between the time to half maximum inotropic effect and the time to maximum of Na⁺ concentrations in human erythrocyte, determined by ²³Na NMR.
关键词：cardiac glycoside;^ Na NMR spectrometry;proscillaridin;inotropy speed;erythrocyte