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  • 标题:AN ACUTE AND FOCAL OSTEOPENIA MODEL USING OVARIECTOMIZED RATS : A RAPID DETECTION OF THE PROTECTIVE EFFECT OF SALMON CALCITONIN
  • 本地全文:下载
  • 作者:Hiromichi NAKAMUTA ; Minoru SASAKI ; Masaki ICHIKAWA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1993
  • 卷号:16
  • 期号:3
  • 页码:325-327
  • DOI:10.1248/bpb.16.325
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:A screening method for anti-osteoporotics using ovariectomized rats was designed using a compact method to monitor the bone density. It was found that ovariectomy (OVX) of Wister female rats (11 weeks old) induced acute and focal osteopenia within 2 weeks, which responded well to intermittent salmon calcitonin (SCT : 5 and 20 U/kg, s.c., every other day) employed as the standard anti-osteoporotic and injected up to 4 weeks with or without a delay of 2 weeks after OVX.
  • 关键词:osteopenia;salmon calcitonin;ovariectomy
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