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  • 标题:IN VITRO CONVERSION OF 2, 3-OXIDOSQUALENE INTO DAMMARENEDIOL BY PANAX GINSENG MICROSOMES
  • 本地全文:下载
  • 作者:Tetsuo KUSHIRO ; Yoshimi OHNO ; Masaaki SHIBUYA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1997
  • 卷号:20
  • 期号:3
  • 页码:292-294
  • DOI:10.1248/bpb.20.292
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:(RS)-[3-3H]-2, 3-Oxidosqualene (1) was converted into (20S)-dammarenediol (2) and not to (20R)-dammarenediol by a microsomal fraction preparaed from the hairy root of Panax ginseng. The enzyme activity was highest at pH 6.0 and was not increased by the addition of any detergents. These properties differed significantly from those of other 2, 3-oxidosqualene cyclases reported from higher plants and animals.
  • 关键词:2, 3-oxidosqualene;dammarenediol;Panax ginseng
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