标题：ABSORPTION OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (rhG-CSP) AND BLOOD LEUKOCYTE DYNAMICS FOLLOWING INTRANASAL ADMINISTRATION IN RABBITS
摘要：Absorption of recombinant human granulocyte colony-stimulating factors (rhG-CSF) following intranasal administration of aqueous preparations containing rhG-CSF with or without dimethyl-β-cyclodextrin was investigated. It was found that rhG-CSF was absorbed and the total leukocyte numbers in peripheral blood markedly increased after intranasal instillation of rhG-CSF solution (pH 4) without excipients. Simultaneously administered dimethyl-β-cyclodextrin enhanced nasal absorption of rhG-CSF. Consequently, serum rhG-CSF concentrations and total leukocyte numbers were greatly increased.
关键词：granulocyte colony-stimulating factor;nasal absorption;dimethyl-β-cyclodextrin;serum rhG-CSF level;blood total leukocyte number
