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  • 标题:AUTOOXIDATION OF ALKYLHYDRAZONES AND MUTAGENICITY OF THE RESULTING HYDROPEROXIDES
  • 本地全文:下载
  • 作者:Masataka MOCHIZUKI ; Kozo MICHIHIRO ; Katsuko SHIOMI
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1993
  • 卷号:16
  • 期号:1
  • 页码:96-98
  • DOI:10.1248/bpb.16.96
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Acetone alkylhydrazones were readily autooxidized to 2-alkylazo-2-propyl hydroperoxides, which were directly mutagenic in Salmonella typhimurium TA1535, TA100, TA102 and Escherichia coli WP2hcr-. The mechanism of this mutagenicity presumes that the hydroperoxides in aqueous solution decompose to alkyl diazonium ions which were observed in the alkylation of 4-(p-nitrobenzyl)pyridine, and also to hydroxyl radical which was detected by ESR.
  • 关键词:alkylhydrazone;mutagenicity;autooxidation;hydroperoxide;alkylation;hydroxyl radical
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