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  • 标题:Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide
  • 本地全文:下载
  • 作者:Rumiko SHIMAZAWA ; Hiroyuki MIYACHI ; Hisae TAKAYAMA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1999
  • 卷号:22
  • 期号:2
  • 页码:224-226
  • DOI:10.1248/bpb.22.224
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived fromthalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.
  • 关键词:thalidomide;antiangiogenesis;phthalimide;tumor necrosis factor-α
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