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  • 标题:The Effect of Ethanolamine on Acute Carbon Tetrachloride Intoxication
  • 本地全文:下载
  • 作者:Takaya MURAKAMI ; Yoichi NAGAMURA ; Kazuyuki HIRANO
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1998
  • 卷号:21
  • 期号:1
  • 页码:84-86
  • DOI:10.1248/bpb.21.84
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The effects of ethanolamine on injured liver were investigated by oral administration of ethanolamine to male ddY mice 24h after carbon tetrachloride (CCl4) injection. The serum aminotransferase activities in mice with liver injury were reduced by ethanolamine treatment (10-30mg/kg body weight). Drastically increased regerative reaction of ethanolamine treated-CCl4 injured liver was also observed through an increase in 5-bromo-2'-deoxyuridine uptake. ATP concentration in liver tissue was recovered by administration of ethanolamine. These results suggest that oral administration of ethanolamine accelerates recovery from CCl4-in-duced liver injury.
  • 关键词:ethanolamine;liver injury;carbon tetrachloride;hepatocellular regeneration;5-bromo-2'-deoxyuridine;ATP
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