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  • 标题:HYPOGLYCEMIC ACTIVITY AND STRUCTURE-ACTIVITY RELATIONSHIP OF IRIDOIDAL GLYCOSIDES
  • 本地全文:下载
  • 作者:Toshihiro MIURA ; Yumi NISHIYAMA ; Momoyo ICHIMARU
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1996
  • 卷号:19
  • 期号:1
  • 页码:160-161
  • DOI:10.1248/bpb.19.160
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Four iridoidal glycosides, deacetylasperulosidic acid methyl ester (DE), scandoside methyl ester (SC), geniposide (GE) and gardenoside (GA) isolated from Gardenia jasminoides Ellis grandiflora Makino leaves, were tested hypoglycemic activity in mice. DE lowered the blood glucose level in normal mice. However, SC, GE and GA did not affect the blood glucose level in normal mice, indicating that the absolute configuration of 6 position hydroxy based (OH) should be essential for the biological activity.
  • 关键词:iridoidal glycoside;deacetylasperulosidic acid methyl ester hypoglycemic activity;structure-activity relationship
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