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  • 标题:Inhibitory Effect of 2, 5-Dimethylpyrazine on Oxytocic Agent -induced Uterine Hypercontraction of Normal or Pregnant Female Rats
  • 本地全文:下载
  • 作者:Kenji Yamada ; Yoshiharu Kobayashi ; Hisato Fujihara
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1998
  • 卷号:21
  • 期号:5
  • 页码:538-540
  • DOI:10.1248/bpb.21.538
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Intraperitoneal administration of 2, 5-dimethylpyrazine (2, 5-DMP) was found to inhibit oxytocin- and prostaglandin F -induced tetanic uterine contractions in normal or pregnant female rats. This suggests that 2, 5-DMP may be used as a countercontraction agent or relaxant for preventing oxytocic agent-induced medical accident including uterine rupture or pressure death of the fetus due to uterine contractions.
  • 关键词:2, 5-Dimethylpyrazine;Rat uterus;Contraction;Oxytocin;Prostaglandin F2α
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