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  • 标题:Ginseng Pretreatment Protects against Transient Global Cerebral Ischemia in the Rat : Measurement of Local Cerebral Glucose Utilization by [14C]Deoxyglucose Autoradiography
  • 本地全文:下载
  • 作者:Seok Rye CHOI ; Hideo SAJI ; Yasuhiko IIDA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1996
  • 卷号:19
  • 期号:4
  • 页码:644-646
  • DOI:10.1248/bpb.19.644
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The effect of ginseng on brain glucose metabolism has been determined in normal and transient cerebral ischemic rat using the autoradiographic [14C]2-deoxyglucose method. Ginseng had no effect on local cerebral glucose utilization (LCGU) in normal rat. By contrast, in rats subjected to 30 min of four vessel occlusion, a significant reduction of LCGU was shown in parts of the cortex and striatum in comparison to the control group. One-week administration of ginseng at 200 mg/kg/d before the occlusion produced an improvement of LCGU compared with the untreated group. These findings indicate that ginseng has some protective effects against brain damage in transient global cerebral ischemia.
  • 关键词:ginseng;cerebral ischemia;local cerebral glucose utilization (LCGU);[14C]2-deoxyglucose
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