文章基本信息

标题：ENHANCEMENT OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR NECROSIS FACTOR α PRODUCTION BY PHENETHYLPHTHALIMIDE ANALOGS
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作者：Keizo SASAKI ; Yoshihiro SHIBATA ; Koji NISHIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：9
页码：1313-1315
DOI：10.1248/bpb.17.1313
出版社：The Pharmaceutical Society of Japan
摘要：Effects of phenyl-, benzyl-, phenethyl-, and phenylpropylphthalimides on 12-O-tetra-decanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-α production by human leukemia cell line HL-60 were examined. Among the four phthalimide derivatives, only phenethylphthalimide showed potent enhancing effect on TNF-α production.
关键词：phthalimide;tumor necrosis factor α;structure-activity relationship