期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2004
卷号：50
期号：6
页码：426-430
DOI：10.3177/jnsv.50.426
出版社：Center for Academic Publications Japan
摘要：The author has previously reported on the higher antioxidative activity in vivo of defatted soybean oncom (D-oncom), fermented defatted soybeans with Neurospora intermedia , in comparison with that of defatted soybeans (DSB). In this paper, the hydrophilic antimutagenicity of D-oncom against N -nitrosodimethylamine (NDMA) was investigated. Water-extract of D-oncom had a stronger antimutagenicity than that of DSB. The main antimutagenic fraction of D-oncom was anionic, and stable against heating at 37°C. Its antimutagenicity was about one sixth of that of ascorbic acid. Actually the fraction scavenged superoxide anions. Therefore, the antimutagenicity of D-oncom against NDMA might be involved in the reduction of oxidative stress by scavenging superoxide anions. Nonetheless the main antimutagenic fraction was not polyphenol, peptide nor nucleotide, its molecular weight being distributed about 5, 000-12, 500.
