期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2000
卷号：46
期号：5
页码：263-265
DOI：10.3177/jnsv.46.263
出版社：Center for Academic Publications Japan
摘要：We measured retinol levels and β-carotene 15, 15'-dioxygenase activity in rats with streptozotocin-induced diabetes mellitus to assess the relationship between the dis-ease and the conversion of β-carotene to retinol. The plasma retinol level was significantly lower in diabetic rats than in control rats, but the hepatic retinol level was significantly higher than the control. The hepatic dioxygenase activity, but not that of the intestinal mu-cosa, was significantly lower in diabetic rats than in control rats. The hepatic dioxygenase activity showed a significant negative correlation with the hepatic retinol levels. The results suggest the disturbed secretion of retinol from the liver and suppression of hepatic dioxy-genase activity by the retinol increased in the liver in diabetic rats.
