期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1999
卷号：45
期号：5
页码：621-632
DOI：10.3177/jnsv.45.621
出版社：Center for Academic Publications Japan
摘要：The characteristic cyclic variation in feed intake of rats fed a Zn-deficient diet (Mills et al, Am J Clin Nutr 22: 1240-1249 (1969)) followed a Cosinor curve, as determined by computer analysis (Tamaki et al, Br J Nutr 73: 711-722 (1995)). The values of amplitude for the feed-intake cycle had a positive correlation to their own day-to-day variations and to the correlation value of their own simulated cycles ( r 2=0, 764, df=50, p <0.001 and r 2=0.682, df=50, p <0.001, respectively). The cyclic variation in feed intake was accompanied by a cyclic variation in body-weight change in rats fed the Zn-deficient diet, and cyclic variation in body-weight change occurred similarly in pair-fed control rats. There were no differences in the mesors of body-weight change cycles of Zn-deficient rats and pair-fed control rats (Zn-deficient rats: 2.5±1.0g/d, pair-fed rats: 2.8±1.0g/d, mean±SD, df=18, t =-0.674, ND). Rats fed the Zn-deficient diet were given different amounts of Zn supplementation by daily subcutaneous injection. The amplitude of the feed-intake cycle was decreased with increasing Zn supplementation ( r 2=0.919, df=5, p <0.001). The concentration of Zn for the appearance of the feed-intake cycle was estimated to be 71.6+6.6μg/d per rat. The Zn level in the serum showed a significant decrease in the Zn-deficient diet groups, but the supplement of Zn did not vary in the Zn-deficient rats injected with up to 47.3μg/d per rat. From these results, an analysis of the feedintake cycle allowed us to estimate the quantitative Zn-deficient status of rats.
