期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1999
卷号：45
期号：4
页码：459-469
DOI：10.3177/jnsv.45.459
出版社：Center for Academic Publications Japan
摘要：We investigated the change of tryptophan-niacin metabolism induced by carbon tetrachloride (CCl4) in rats with liver cirrhosis. The rats were injected with CCl4 (0.5 or 1mL of 50% olive oil solution/kg body weight) twice a week for 1 or 2 mo and given phenobarbital water simultaneously. The urinary excretions of nicotinamide (Nam) and its metabolites were assayed. As the result, the urinary excretion of Nam, N 1-methyl-4-pyridone-3-carboxamide (4-Py), Nam+ N 1-methylnicotinamide (MNA)+ N 1-methyl-2-pyridone-5-carboxamide (2-Py)+4-Py was lower in the CCl4-treated groups than in the non-treated group (control) regardless of the experimental period (1 mo and 2 mo) or dosing amount of CCl4 (0.5 and 1mL), Moreover, we investigated which pathway of tryptophan-niacin metabolism was affected in CCl4-treated rat. As the result, the possibility that the MNA→+4-Py reaction is inhibited by CCl4 treatment was suggested in this experiment.
